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Creating Molecular Probes to Study Interactions in Biology

Welcome to the website of the Butler Research Group. We are based in the Chemistry Department at Loughborough University. Research in the Butler Group is focused on the synthesis of supramolecular tools to probe interactions at the chemistry/biology interface. We are developing fluorescent and luminescent molecular probes for the selective detection of biological substrates. We are applying these probes to monitor biological processes in real-time, such as tracking enzyme activity in vitro and in living cells, to facilitate the discovery of new potent drugs.

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Our research is multidisciplinary in nature, spanning organic synthesis, physical organic chemistry techniques, molecular recognition, optical spectroscopy, bioassay development and cellular imaging. 

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If you are interested in joining the Butler Group please contact Steve for an informal discussion about opportunities, or if you would like to apply for external funding to join the group. We are always looking for keen scientists to join our team!

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Latest News

Congratulations, Dr Webb!

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May 2025

We are delighted to congratulate Jamie on passing his PhD viva with minor corrections! Thanks to Prof. Simon Lewis and Prof. Steve Christie for examining Jamie’s PhD thesis.

​2nd Global Action Meeting (GAM) of the LUCES COST Action

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May 2025

Tony, Dom and Lea attended and presented at 2nd Global Action Meeting of the LUCES COST action in May 2025. Lea won a first place poster prize, Dom presented his first ever flash talk at an international conference and Tony presented a 15 minute presentation, gaining interest from supervisors intersted in using Array-based systems. Well done, everyone!

Welcome Back, Dom! 

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January 2025

Welcome back, Dom! Dom is continuing research in the Butler group as a PDRA for the next 3 years on a multi-disciplinary EPSRC project using Ln-containing macrocyclic luminescent probes to detect specific analytes in vapour and liquid.

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