top of page

Creating Molecular Probes to Study Interactions in Biology

Welcome to the website of the Butler Research Group. We are based in the Chemistry Department at Loughborough University. Research in the Butler Group is focused on the synthesis of supramolecular tools to probe interactions at the chemistry/biology interface. We are developing fluorescent and luminescent molecular probes for the selective detection of biological substrates. We are applying these probes to monitor biological processes in real-time, such as tracking enzyme activity in vitro and in living cells, to facilitate the discovery of new potent drugs.

​

Our research is multidisciplinary in nature, spanning organic synthesis, physical organic chemistry techniques, molecular recognition, optical spectroscopy, bioassay development and cellular imaging. 

​

If you are interested in joining the Butler Group please contact Steve for an informal discussion about opportunities, or if you would like to apply for external funding to join the group. We are always looking for keen scientists to join our team!

white hart.png

Latest News

**Funded PhD Position Available**

jobsacuk_logo.jfif

December 2024

We invite applications PhD position in organic synthesis and supramolecular chemistry. This PhD project focuses on design and synthesis of luminescent molecular probes to detect short-lived reactive species across biological, environmental, and security settings. The student will receive training in organic synthesis, host-guest interactions, and photophysical analysis of lanthanide complexes, alongside expertise in assay development for real-world applications. Informal enquiries are welcome and should be made to Dr Stephen Butler by email at s.j.butler@lboro.ac.uk. Closing date for applications is 19th February 2025, to apply please follow this link.

Congratulations Hannah!

EXAFS.jpg

December 2024

We are delighted to congratulate Hannah for passing her PhD viva with very minor corrections. Thanks to Dr Rama Suntharalingam and Dr George Weaver for examining Hannah’s PhD thesis. Hannah’s first paper, published in Inorganic Chemistry, combines EPR with EXAFS spectroscopy to elucidate anion binding geometries at lanthanide centres in water. Read about it here.

Tetralactam-based Anion Transporters

pic for news.png

November 2024

A collaborative paper led by Prof. Phil Gale’s team is published in Chem, presenting the most active synthetic transporter for chloride reported to date. This collaboration resulted from Steve’s sabbatical in Sydney in early 2023, where he worked with lead author Alex to monitor fluoride/chloride transport across lipid vesicles using emissive lanthanide probes.

Welcome to PhD students Erin and Maryam!

white hart.png

October 2024

We welcome Erin and Maryam to the group. Erin will be developing the new lanthanide tags for protein labelling, in collaboration with ARC CIPPS partners Prof. Otting and Prof. Jolliffe. Maryam will be developing lanthanide-based anion receptors with strong binding preferences.

bottom of page